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Syndax  
Syndax制藥專注于運用表觀遺傳學相關的方法，克服在實體瘤治療中發生的耐藥性問題。公司擁有Entinostat在全球的專利權。Entinostat是一種口服的、高選擇性的組蛋白去乙酰化酶（HDAC）抑制劑，用于晚期乳腺癌和肺癌的臨床治療。同樣在一組非小細胞肺癌患者的治療中（ENCORE401），Entinostat與EGFR-TKI厄洛替尼配合使用也取得了積極有效的結果。美國國家癌癥研究所（NCI）和Syndax制藥就Entinostat的發展達成了合作研究和開發協議，旨在改善晚期癌癥和難治性癌癥的存活率。

Syndax is focused on employing epigenetic strategies to overcome the problem of resistance in oncology care in solid tumors. The company holds worldwide rights to entinostat, an oral, highly selective histone deacetylase (HDAC) inhibitor in late-stage clinical development for the treatment of advanced breast cancer and lung cancer. A randomized, placebo-controlled Phase 2 study of entinostat in combination with aromatase inhibitors in breast cancer (ENCORE 301) demonstrated an improvement in both progression-free survival and overall survival, providing the basis for the evaluation of entinostat in pivotal Phase 3 testing in metastatic breast cancer. Entinostat also demonstrated promising results in a subset of non-small cell lung cancer patients when given in combination with the EGFR-TKI erlotinib (ENCORE 401). NCI and Syndax are collaborating on the development of entinostat under a Cooperative Research and Development Agreement aimed at improving survival in advanced, hard-to-treat cancers.

Read more: Syndax's Entinostat Receives Breakthrough Therapy Designation from FDA for Treatment of Advanced Breast Cancer - FierceBiotech http://www.fiercebiotech.com/press-releases/syndaxs-entinostat-receives-breakthrough-therapy-designation-fda-treatment#ixzz2ejNENL8W
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